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Description

Ureidopeptide GLP1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking

Unfortunately, these anti-IGF-1R agents have very limited efficacy in clinical trials, 7,8,9 suggesting the existence of a mechanism to antagonize the IGF-1R inhibition in cancer cells

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In an experiment investigating its protective effects in mice with gouty arthritis, trans-Chalcone pre-treatment was administered to mice that were then injected in the joints with MSU